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Chemical Structure : Paprotrain
CAS No.: 57046-73-8
Catalog No.: PC-22648Not For Human Use, Lab Use Only.
Paprotrain is a selective, reversible inhibitor of KIF20A (mitotic kinesin-like protein 2, MKLP-2, MKlp2) with Ki of 3.4 uM, does not inhibit other members of the kinesin superfamily.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | Get quote |
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Paprotrain is a selective, reversible inhibitor of KIF20A (mitotic kinesin-like protein 2, MKLP-2, MKlp2) with Ki of 3.4 uM, does not inhibit other members of the kinesin superfamily.
Paprotrain exhibits IC50 values of 1.35 μM in basal and 0.83 μM in MT-stimulated ATPase assays.
Paprotrain is cell permeable and incubation with 10 to 50 μM inhibitor results in binucleated cells, a characteristic phenotype similar to that observed following RNAi-mediated depletion of MKLP-2.
Paprotrain induces mitotic spindle defects, perturbs MKLP-2-mediated relocation of the chromosome passenger proteins Aurora B and survivin from the centromeres to the central spindle.
Paprotrain does not impair kinesin family member 4 (Kif4)-mediated translocation of protein regulating cytokinesis 1 (PRC1), which emphasizes its specificity for MKLP-2.
| M.Wt | 245.29 | |
| Formula | C16H11N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile |
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1. Tcherniuk S, et al. Angew Chem Int Ed Engl. 2010 Oct 25;49(44):8228-31.
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