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Chemical Structure : Parmodulin 2
CAS No.: 423735-93-7
Catalog No.: PC-62640Not For Human Use, Lab Use Only.
Parmodulin 2 (ML161) is a potent, specific antagonist of PAR-1, specifically inhibits thrombin-tethered ligand (TL) peptide-mediated platelet aggregation with IC50 of 7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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Parmodulin 2 (ML161) is a potent, specific antagonist of PAR-1, specifically inhibits thrombin-tethered ligand (TL) peptide-mediated platelet aggregation with IC50 of 7 uM.
Parmodulin 2 promotes biased PAR1 signaling by preferentially blocking Gαq- over Gα12/13-mediated PAR1 signaling, restricts mTORC1 and Nlrp3 inflammasome activation and limited myocardial ischemia-reperfusion injury.
| M.Wt | 361.239 | |
| Formula | C17H17BrN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-bromo-N-(3-butyramidophenyl)benzamide |
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1. Nazir S, et al. Blood. 2017 Dec 14;130(24):2664-2677.
2. van den Eshof BL, et al. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1891-1902.
3. Aisiku O, et al. Blood. 2015 Mar 19;125(12):1976-85.
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