Catalog No.: PC-62640Not For Human Use, Lab Use Only.
Parmodulin 2 (ML161) is a potent, specific antagonist of PAR-1, specifically inhibits thrombin-tethered ligand (TL) peptide-mediated platelet aggregation with IC50 of 7 uM.
Parmodulin 2 (ML161) is a potent, specific antagonist of PAR-1, specifically inhibits thrombin-tethered ligand (TL) peptide-mediated platelet aggregation with IC50 of 7 uM.
Parmodulin 2 promotes biased PAR1 signaling by preferentially blocking Gαq- over Gα12/13-mediated PAR1 signaling, restricts mTORC1 and Nlrp3 inflammasome activation and limited myocardial ischemia-reperfusion injury.
Physicochemical Properties
M.Wt
361.239
Formula
C17H17BrN2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-bromo-N-(3-butyramidophenyl)benzamide
References
1. Nazir S, et al. Blood. 2017 Dec 14;130(24):2664-2677.
2. van den Eshof BL, et al. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1891-1902.
3. Aisiku O, et al. Blood. 2015 Mar 19;125(12):1976-85.
