Peficitinib (ASP015K, JNJ-54781532)

You are here:Home-Chemical Inhibitors & Agonists-JAK/STAT Signaling-JAK-Peficitinib

Chemical Structure : Peficitinib

CAS No.: 944118-01-8

Catalog No.: PC-45652Not For Human Use, Lab Use Only.

Peficitinib (ASP015K, JNJ-54781532) is a potent JAK inhibitor with IC50s of 3.9 and 0.7 nM for JAK1 and JAK3 respectively.

Packing	Price	Stock
10 mg	$98	In stock
25 mg	$158	In stock
50 mg	$248	In stock
100 mg	$398	In stock
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Peficitinib (ASP015K, JNJ-54781532) is a potent JAK inhibitor with IC50s of 3.9 and 0.7 nM for JAK1 and JAK3 respectively.
Peficitinib inhibits IL-2-dependent T cell proliferation in vitro and STAT5 phosphorylation in vitro and ex vivo.
Peficitinib dose-dependently suppresses bone destruction and paw swelling in an adjuvant-induced arthritis model in rats; orally bioactive.

Physicochemical Properties

M.Wt	326.3929
Formula	C18H22N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 60 mg/mL
Chemical Name/SMILES	1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, 4-[(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)amino]-, stereoisomer

References

1. Oda K, et al. Xenobiotica. 2015;45(6):488-94.

2. Takeuchi T, et al. Ann Rheum Dis. 2016 Jun;75(6):1057-64.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com