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Chemical Structure : Peficitinib
CAS No.: 944118-01-8
Catalog No.: PC-45652Not For Human Use, Lab Use Only.
Peficitinib (ASP015K, JNJ-54781532) is a potent JAK inhibitor with IC50s of 3.9 and 0.7 nM for JAK1 and JAK3 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $398 | In stock | |
| 250 mg | Get quote |
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Peficitinib (ASP015K, JNJ-54781532) is a potent JAK inhibitor with IC50s of 3.9 and 0.7 nM for JAK1 and JAK3 respectively.
Peficitinib inhibits IL-2-dependent T cell proliferation in vitro and STAT5 phosphorylation in vitro and ex vivo.
Peficitinib dose-dependently suppresses bone destruction and paw swelling in an adjuvant-induced arthritis model in rats; orally bioactive.
| M.Wt | 326.3929 | |
| Formula | C18H22N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 60 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, 4-[(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)amino]-, stereoisomer |
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1. Oda K, et al. Xenobiotica. 2015;45(6):488-94.
2. Takeuchi T, et al. Ann Rheum Dis. 2016 Jun;75(6):1057-64.
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