Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Pemafibrate
CAS No.: 848259-27-8
Catalog No.: PC-45390Not For Human Use, Lab Use Only.
Pemafibrate (K-877) is a highly potent, specific PPARα agonist with EC50 of 1 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Pemafibrate (K-877) is a highly potent, specific PPARα agonist with EC50 of 1 nM.
Pemafibrate (K-877) displays >2,000-fold selectivity for PPARα over others subtypes in a CHO cell-based transactivation assay.
Pemafibrate (K-877) upregulates the expression of several fatty acid β-oxidative genes in human hepatocytes and the mouse liver.
Pemafibrate (K-877) significantly induces the expression of clinically beneficial target genes (VLDLR, FGF21, ABCA1, MBL2, ENPEP) in human hepatocytes.
| M.Wt | 490.5476 | |
| Formula | C28H30N2O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: 2.45 mg/mL (5 mM) |
|
| Chemical Name/SMILES |
Butanoic acid, 2-[3-[[2-benzoxazolyl[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]-, (2R)- |
|
1. Ishibashi S, et al. Atherosclerosis. 2016 Jun;249:36-43.
2. Yamazaki Y, et al. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4689-93.
3. Raza-Iqbal S, et al. J Atheroscler Thromb. 2015 Aug 26;22(8):754-72.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
