Pemafibrate | PPARα agonist | Probechem Biochemicals

Chemical Structure : Pemafibrate

CAS No.: 848259-27-8

Pemafibrate (K-877, (R)-K-13675)

Catalog No.: PC-45390Not For Human Use, Lab Use Only.

Pemafibrate (K-877) is a highly potent, specific PPARα agonist with EC50 of 1 nM.

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Biological Activity

Pemafibrate (K-877) is a highly potent, specific PPARα agonist with EC50 of 1 nM.
Pemafibrate (K-877) displays >2,000-fold selectivity for PPARα over others subtypes in a CHO cell-based transactivation assay.
Pemafibrate (K-877) upregulates the expression of several fatty acid β-oxidative genes in human hepatocytes and the mouse liver.
Pemafibrate (K-877) significantly induces the expression of clinically beneficial target genes (VLDLR, FGF21, ABCA1, MBL2, ENPEP) in human hepatocytes.

Physicochemical Properties

M.Wt	490.5476
Formula	C28H30N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 2.45 mg/mL (5 mM)
Chemical Name/SMILES	Butanoic acid, 2-[3-[[2-benzoxazolyl[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]-, (2R)-

References

1. Ishibashi S, et al. Atherosclerosis. 2016 Jun;249:36-43.

2. Yamazaki Y, et al. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4689-93.

3. Raza-Iqbal S, et al. J Atheroscler Thromb. 2015 Aug 26;22(8):754-72.

Pemafibrate (K-877, (R)-K-13675)

Biological Activity

Physicochemical Properties

References

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