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Chemical Structure : Pemafibrate
CAS No.: 848259-27-8
Catalog No.: PC-45390Not For Human Use, Lab Use Only.
Pemafibrate (K-877) is a highly potent, specific PPARα agonist with EC50 of 1 nM.
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|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Pemafibrate (K-877) is a highly potent, specific PPARα agonist with EC50 of 1 nM.
Pemafibrate (K-877) displays >2,000-fold selectivity for PPARα over others subtypes in a CHO cell-based transactivation assay.
Pemafibrate (K-877) upregulates the expression of several fatty acid β-oxidative genes in human hepatocytes and the mouse liver.
Pemafibrate (K-877) significantly induces the expression of clinically beneficial target genes (VLDLR, FGF21, ABCA1, MBL2, ENPEP) in human hepatocytes.
| M.Wt | 490.5476 | |
| Formula | C28H30N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
Butanoic acid, 2-[3-[[2-benzoxazolyl[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]-, (2R)- |
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1. Ishibashi S, et al. Atherosclerosis. 2016 Jun;249:36-43.
2. Yamazaki Y, et al. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4689-93.
3. Raza-Iqbal S, et al. J Atheroscler Thromb. 2015 Aug 26;22(8):754-72.
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