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Chemical Structure : Perforin inhibitor 16
Catalog No.: PC-73073Not For Human Use, Lab Use Only.
Perforin inhibitor 16 (Perforin-IN-16) is a small molecule Perforin inhibitor with IC50 of 1.13 uM in KHYG1 assay.
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Perforin inhibitor 16 (Perforin-IN-16) is a small molecule Perforin inhibitor with IC50 of 1.13 uM in KHYG1 assay.
Perforin inhibitor 16 preserves transferred MHC-mismatched cells in a short term mouse
model of bone marrow stem cell transplantation.
Perforin inhibitor 16 is the first reported small molecule able to prevent rejection of transplanted bone marrow stem cells in vivo by blocking perforin function.
Perforin is a key effector protein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes and natural killer cells to help eliminate virus-infected and transformed target cells.
| M.Wt | 528.549 | |
| Formula | C24H18F2N4O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Spicer JA, et al. J Med Chem. 2020 Mar 12;63(5):2229-2239.
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