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Perforin inhibitor 5

Chemical Structure : Perforin inhibitor 5

CAS No.: 1567836-38-7

Perforin inhibitor 5

Catalog No.: PC-20610Not For Human Use, Lab Use Only.

Perforin inhibitor 5 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 1.17 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Perforin inhibitor 5 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 1.17 uM.

Physicochemical Properties

M.Wt 497.53
Formula C24H17F2N3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=S(C1=CC=C(F)C=C1F)(NC2=CC(C3=CC=C(C4=CC5=C(C(N(C)C5)=O)C=C4)S3)=CN=C2)=O

References

1. Julie A. Spicer, et al. J. Med. Chem. 2022, 65, 21, 14305–14325

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