Catalog No.: PC-45903Not For Human Use, Lab Use Only.
Perifosine (KRX-0401, D21266) is an oral bioavailable alkylphospholipid, acts as an Akt inhibitor and a PI3K inhibitor, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway.
Perifosine (KRX-0401, D21266) is an oral bioavailable alkylphospholipid, acts as an Akt inhibitor and a PI3K inhibitor, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway.
Perifosine enhances apoptosis and inhibits the growth of xenografts in nude mice combined with a lysosomal inhibitor.
Perifosine displays significant antiproliferative activity in vitro and in vivo in several human tumor model
Physicochemical Properties
M.Wt
461.6584
Formula
C25H52NO4P
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt
References
1. Kondapaka SB, et al. Mol Cancer Ther. 2003 Nov;2(11):1093-103.
2. Patel V, et al. Cancer Res. 2002 Mar 1;62(5):1401-9.
3. Becher OJ, et al. Cancer Res. 2010 Mar 15;70(6):2548-57.
