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Chemical Structure : Perifosine
CAS No.: 157716-52-4
Catalog No.: PC-45903Not For Human Use, Lab Use Only.
Perifosine (KRX-0401, D21266) is an oral bioavailable alkylphospholipid, acts as an Akt inhibitor and a PI3K inhibitor, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Perifosine (KRX-0401, D21266) is an oral bioavailable alkylphospholipid, acts as an Akt inhibitor and a PI3K inhibitor, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway.
Perifosine enhances apoptosis and inhibits the growth of xenografts in nude mice combined with a lysosomal inhibitor.
Perifosine displays significant antiproliferative activity in vitro and in vivo in several human tumor model
| M.Wt | 461.6584 | |
| Formula | C25H52NO4P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt |
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1. Kondapaka SB, et al. Mol Cancer Ther. 2003 Nov;2(11):1093-103.
2. Patel V, et al. Cancer Res. 2002 Mar 1;62(5):1401-9.
3. Becher OJ, et al. Cancer Res. 2010 Mar 15;70(6):2548-57.
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