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PfHsp70-1 inhibitor AMK3

Chemical Structure : PfHsp70-1 inhibitor AMK3

CAS No.: 1203159-24-3

PfHsp70-1 inhibitor AMK3

Catalog No.: PC-27251Not For Human Use, Lab Use Only.

PfHsp70-1 inhibitor AMK3 is a potent, high affinity and selective inhibitor of Plasmodium falciparum chaperone PfHsp70-1 with MST Kd of 0.82 uM, binds to the PfHsp70-1 N-terminal NBD and competes for ATP binding, has >25-fold for PfHsp70-1 over the human homolog HSPA1A.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PfHsp70-1 inhibitor AMK3 is a potent, high affinity and selective inhibitor of Plasmodium falciparum chaperone PfHsp70-1 with MST Kd of 0.82 uM, binds to the PfHsp70-1 N-terminal NBD and competes for ATP binding, has >25-fold for PfHsp70-1 over the human homolog HSPA1A.

Physicochemical Properties

M.Wt 395.43
Formula C22H17N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-((6-(1H-imidazol-1-yl)pyrimidin-4-yl)amino)phenyl)-1H-indole-3-carboxamide

References

1. Keeler AM, et al. Antimicrob Agents Chemother. 2026 Jul 2:e0046626.

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