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PfHsp70-1 inhibitor AMK4

Chemical Structure : PfHsp70-1 inhibitor AMK4

CAS No.: 1026524-67-3

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PfHsp70-1 inhibitor AMK4

Catalog No.: PC-27252Not For Human Use, Lab Use Only.

PfHsp70-1 inhibitor AMK4 is a selective inhibitor of Plasmodium falciparum chaperone PfHsp70-1 with MST Kd of 41 uM,binds to substrate-binding domain (SBD) and leads to disruption in peptide binding, has >25-fold for PfHsp70-1 over the human homolog HSPA1A.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PfHsp70-1 inhibitor AMK4 is a selective inhibitor of Plasmodium falciparum chaperone PfHsp70-1 with MST Kd of 41 uM,binds to substrate-binding domain (SBD) and leads to disruption in peptide binding, has >25-fold for PfHsp70-1 over the human homolog HSPA1A.

Physicochemical Properties

M.Wt 305.34
Formula C18H15N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-6-phenylpyrimidin-4-amine

References

1. Keeler AM, et al. Antimicrob Agents Chemother. 2026 Jul 2:e0046626.

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