Catalog No.: PC-26811Not For Human Use, Lab Use Only.
Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent that inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy.
Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent that inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy.
Physicochemical Properties
M.Wt
205.27
Formula
C10H15N5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-Phenethylbiguanide
References
1. García Rubiño ME, et al. Int J Mol Sci. 2019;20(13):3316. Published 2019 Jul 5.
2. Hu S, et al. Mol Med Rep. 2018;17(4):6028-6032.
