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Chemical Structure : Piezo1 agonist 12a
Catalog No.: PC-23357Not For Human Use, Lab Use Only.
Piezo1 agonist 12a is a potent small-molecule Piezo1 agonist with EC50 of 2.21 uM, 20-fold more potent than Yoda1.
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Piezo1 agonist 12a is a potent small-molecule Piezo1 agonist with EC50 of 2.21 uM, 20-fold more potent than Yoda1.
Piezo1 agonist 12a effectively activates Piezo1 and initiated Ca2+ influx in MSCs and promoted MSC osteogenesis via activating the Ca2+-related Erk signaling pathway.
Piezo1 agonist 12a alleviates disuse osteoporosis with a desirable safety profile in a HU (hindlimb-unloading) rat model.
| M.Wt | 430.36 | |
| Formula | C16H13D2Cl2N5OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tang H, et al. J Med Chem. 2024 Oct 27. doi: 10.1021/acs.jmedchem.4c02224.
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