Piezo1 agonist 12a

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Chemical Structure : Piezo1 agonist 12a

Catalog No.: PC-23357Not For Human Use, Lab Use Only.

Piezo1 agonist 12a is a potent small-molecule Piezo1 agonist with EC50 of 2.21 uM, 20-fold more potent than Yoda1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Piezo1 agonist 12a is a potent small-molecule Piezo1 agonist with EC50 of 2.21 uM, 20-fold more potent than Yoda1.
Piezo1 agonist 12a effectively activates Piezo1 and initiated Ca2+ influx in MSCs and promoted MSC osteogenesis via activating the Ca2+-related Erk signaling pathway.
Piezo1 agonist 12a alleviates disuse osteoporosis with a desirable safety profile in a HU (hindlimb-unloading) rat model.

Physicochemical Properties

M.Wt	430.36
Formula	C16H13D2Cl2N5OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-((5-(5-(((2,6-dichlorophenyl)methyl-d2)thio)-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)amino)propan-2-ol

References

1. Tang H, et al. J Med Chem. 2024 Oct 27. doi: 10.1021/acs.jmedchem.4c02224.

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