Pim-IN-22m |CAS:1405126-60-4 Probechem Biochemicals

Chemical Structure : Pim-IN-22m

Pim-IN-22m

Catalog No.: PC-62787Not For Human Use, Lab Use Only.

Pim-IN-22m is a potent, selective Pim1/Pim2 inhibitor with IC50 of 24/95 pM respectively.

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Biological Activity

Pim-IN-22m is a potent, selective Pim1/Pim2 inhibitor with IC50 of 24/95 pM respectively.
Pim-IN-22mpotently inhibits the phosphorylation of BAD (s112) in a cell line that expresses high levels of all Pim isoforms, KMS-12-BM (IC50=28 nM).

Physicochemical Properties

M.Wt	435.483
Formula	C23H23F2N7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((3S,5R)-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine

References

1. Wurz RP, et al. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5580-5590.

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Pim-IN-22m

Biological Activity

Physicochemical Properties

References

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