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Pimelic Diphenylamide 106

Chemical Structure : Pimelic Diphenylamide 106

CAS No.: 937039-45-7

Pimelic Diphenylamide 106 (RGFA-8;TC-H 106;BRD-4657)

Catalog No.: PC-45618Not For Human Use, Lab Use Only.

A slow, tight-binding inhibitor of class I HDACs (HDAC1/2/3, Ki=148/102/14 nM respectively).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A slow, tight-binding inhibitor of class I HDACs (HDAC1/2/3, Ki=148/102/14 nM respectively); shows weak inhibition on HDAC8 (IC50=5 uM); has preference toward HDAC3.

Physicochemical Properties

M.Wt 339.4314
Formula C20H25N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 25 mg/mL

Chemical Name/SMILES

Heptanediamide, N1-(2-aminophenyl)-N7-(4-methylphenyl)-

References

1. Chou CJ, et al. J Biol Chem. 2008 Dec 19;283(51):35402-9.

2. Xu C, et al. Chem Biol. 2009 Sep 25;16(9):980-9.

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