Pin1 inhibitor H-77

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Chemical Structure : Pin1 inhibitor H-77

Catalog No.: PC-73344Not For Human Use, Lab Use Only.

Pin1 inhibitor H-77 (H-77) is a small molecule Pin1 inhibitor that blocks SARS-CoV-2 proliferation with EC50 of 3.2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pin1 inhibitor H-77 (H-77) is a small molecule Pin1 inhibitor that blocks SARS-CoV-2 proliferation with EC50 of 3.2 uM.
H-77 exhibited strong inhibitory effects on SARS-CoV-2 proliferation regardless of whether it was added to the culture medium prior to or after SARS-CoV-2 infection, measured by both viral mRNA and protein synthesis, and alleviated the cytopathic effect (CPE) on VeroE6/TMPRSS2 cells.
Pin1 inhibitors could serve as potential therapeutic agents for COVID-19.

Physicochemical Properties

M.Wt	397.430
Formula	C25H19NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-naphthamido)-5-(benzyloxy)benzoic acid

References

1. Takeshi Yamamotoya, et al. Sci Rep. 2021 Sep 17;11(1):18581.

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