Catalog No.: PC-38369Not For Human Use, Lab Use Only.
Pirepemat (IRL752) is a new phenyl-pyrrolidine derivative and cognition-promoting agent with regioselective central nervous system transmission-enhancing properties, enhances norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex.
Pirepemat (IRL752) is a new phenyl-pyrrolidine derivative and cognition-promoting agent with regioselective central nervous system transmission-enhancing properties, enhances norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex.
Pirepemat (IRL752) normalized tetrabenazine-induced hypoactivity, whereas it was unable to stimulate basal locomotion in normal animals or either accentuate or reverse hyperactivity induced by amphetamine or MK-801.
IRL752 induced but minor changes in monoaminergic tissue neurochemistry across noradrenaline (NA)- and dopamine (DA)-dominated brain regions.
Physicochemical Properties
M.Wt
213.228
Formula
C11H13F2NO
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(3S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine
References
1. Svenningsson P, et al. Mov Disord. 2020 Jun;35(6):1046-1054.
