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Pirepemat

Chemical Structure : Pirepemat

CAS No.: 1227638-29-0

Pirepemat (IRL752)

Catalog No.: PC-38369Not For Human Use, Lab Use Only.

Pirepemat (IRL752) is a new phenyl-pyrrolidine derivative and cognition-promoting agent with regioselective central nervous system transmission-enhancing properties, enhances norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex.

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    Biological Activity

    Pirepemat (IRL752) is a new phenyl-pyrrolidine derivative and cognition-promoting agent with regioselective central nervous system transmission-enhancing properties, enhances norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex.
    Pirepemat (IRL752) normalized tetrabenazine-induced hypoactivity, whereas it was unable to stimulate basal locomotion in normal animals or either accentuate or reverse hyperactivity induced by amphetamine or MK-801.
    IRL752 induced but minor changes in monoaminergic tissue neurochemistry across noradrenaline (NA)- and dopamine (DA)-dominated brain regions.

    Physicochemical Properties

    M.Wt 213.228
    Formula C11H13F2NO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (3S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine

    References

    1. Svenningsson P, et al. Mov Disord. 2020 Jun;35(6):1046-1054.

    2. Hjorth S, et al. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419.

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