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Chemical Structure : Piromelatine
Catalog No.: PC-61335Not For Human Use, Lab Use Only.
A novel melatonin melatonin receptor MT1/MT2 and serotonin 5-HT1A/5-HT1D receptor agonist.
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A novel melatonin melatonin receptor MT1/MT2 and serotonin 5-HT1A/5-HT1D receptor agonist; inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats; facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease.
Alzheimer Disease
Phase 2 Clinical
| M.Wt | 312.32 | |
| Formula | C17H16N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. She M, et al. Eur J Pharmacol. 2014 Mar 15;727:60-5.
2. Liu YY, et al. Psychopharmacology (Berl). 2014 Oct;231(20):3973-85.
3. She M, et al. Pharmacol Res. 2009 Apr;59(4):248-53.
4. Zhou J, et al. J Pharmacol Exp Ther. 2018 Jan;364(1):55-69.
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