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Pitstop 1

Chemical Structure : Pitstop 1

CAS No.: 1332879-51-2

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Pitstop 1 (Pitstop-1;Pitstop1)

Catalog No.: PC-60189Not For Human Use, Lab Use Only.

A potent, selective inhibitor of clathrin-independent endocytosis with IC50 of 18 uM (inhibition of clathrin TD-amphiphysin B/C complex formation).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Pitstop 1 is a potent, selective inhibitor of clathrin-independent endocytosis with IC50 of 18 uM (inhibition of clathrin TD-amphiphysin B/C complex formation).
    Pitstop 1 inhibits endocytic recycling of synaptic vesicles in neurons and in situ.

    Physicochemical Properties

    M.Wt 404.37
    Formula C19H13N2NaO5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-Aminobenzyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-5-sulfonic acid sodium salt

    References

    1. von Kleist L, et al. Cell. 2011 Aug 5;146(3):471-84.

    2. Nilewski LG, et al. ACS Chem Neurosci. 2017 Aug 14. doi: 10.1021/acschemneuro.7b00138.

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