Pixatimod | Heparanase inhibitor | Probechem Biochemicals

Chemical Structure : Pixatimod

Pixatimod (PG545)

Catalog No.: PC-72855Not For Human Use, Lab Use Only.

Pixatimod (PG545) is a heparan sulfate (HS) mimetic and anticancer agent and a potent inhibitor of heparanase.

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Biological Activity

Pixatimod (PG545) is a heparan sulfate (HS) mimetic and anticancer agent and a potent inhibitor of heparanase.
PG545 is a novel immunomodulatory agent, which has been demonstrated to stimulate innate immune responses against tumours in preclinical cancer models.
PG545 is a potent inhibitor of Th1/Th17 effector functions and inducer of FoxP3+ Treg.
PG545 is a highly potent inhibitor of angiogenesis, tumor growth, and metastasis currently in clinical trials for cancer.

Physicochemical Properties

M.Wt	2078.1
Formula	C51H88O60S13
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R,4S,5R,6R)-2-(((2R,3R,4S,5R,6R)-6-(((2R,3R,4S,5R,6R)-6-(((2R,3R,4S,5R,6R)-6-(((3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4,5-bis(sulfooxy)-2-((sulfooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(sulfooxy)-2-((sulfooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(sulfooxy)-2-((sulfooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-6-((sulfooxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(hydrogen sulfate)

References

1. Chhabra M, et al. Bioconjug Chem. 2021 Nov 17;32(11):2420-2431.

2. Kinaneh S, et al. Biosci Rep. 2021 Jul 30;41(7):BSR20210290.

3. Hammond E, et al. Adv Exp Med Biol. 2020;1221:539-565.

4. Dredge K, et al. Br J Cancer. 2018 Apr;118(8):1035-1041.

Pixatimod (PG545)

Biological Activity

Physicochemical Properties

References

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