Plerixafor octahydrochloride | CXCR4 inhibitor

Chemical Structure : Plerixafor octahydrochloride

CAS No.: 155148-31-5

Plerixafor octahydrochloride (AMD3100 octahydrochloride, JM-3100 octahydrochloride, SID-791 octahydrochloride)

Catalog No.: PC-45905Not For Human Use, Lab Use Only.

Plerixafor octahydrochloride (JM-3100, AMD3100, SID-791) is a potent, selective CXCR4 inhibitor (IC50=44 nM) that inhibits the replication of various HIV-1 and HIV-2 strains in various cell lines with EC50 of 10 ng/ml.

Packing	Price	Stock
10 mg	$68	In stock
25 mg	$98	In stock
50 mg	$148	In stock
100 mg	$228	In stock
250 mg		Get quote

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Biological Activity

Plerixafor octahydrochloride (JM-3100, AMD3100, SID-791) is a potent, selective CXCR4 inhibitor (IC50=44 nM) that inhibits the replication of various HIV-1 and HIV-2 strains in various cell lines with EC50 of 10 ng/ml.
Plerixafor octahydrochloride (JM-3100, AMD3100) can produce mesenchymal stem cells and endothelial progenitor cells in mice in combination with VEGF.
Plerixafor octahydrochloride (JM-3100, AMD3100) also is an allosteric agonist of CXCR7.

Physicochemical Properties

M.Wt	794.4695
Formula	C28H62Cl8N8
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	H2O: ≥ 42 mg/mL
Chemical Name/SMILES	1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-, hydrochloride (1:8)

References

1. Zabel BA, et al. J Immunol. 2009, 183(5), 3204-3211.

2. De Clercq E, et al. Antimicrob Agents Chemother. 1994 Apr;38(4):668-74.

3. Pitchford SC, et al. Cell Stem Cell. 2009 Jan 9;4(1):62-72.

Plerixafor octahydrochloride (AMD3100 octahydrochloride, JM-3100 octahydrochloride, SID-791 octahydrochloride)

Biological Activity

Physicochemical Properties

References

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