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Chemical Structure : Pluripotin
CAS No.: 839707-37-8
Catalog No.: PC-42663Not For Human Use, Lab Use Only.
Pluripotin(SC1) is a small molecule that can maintain the self-renewal of mESC (murine embryonic stem cells) in the absence of feeder cells and exogenous factors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Pluripotin(SC1) is a small molecule that can maintain the self-renewal of mESC (murine embryonic stem cells) in the absence of feeder cells and exogenous factors.
Pluripotin works through dual inhibition of RasGAP and ERK1.
Pluripotin maintains the undifferentiated phenotype of mES cells with EC50 of 1 uM, and shows low cellular toxicity (>30 uM).
| M.Wt | 550.535 | |
| Formula | C27H25F3N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)- |
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1. Chen S, et al. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17266-71.
2. Yang W, et al. Stem Cells. 2009 Feb;27(2):383-9.
3. Pieters T, et al. Stem Cell Rev. 2012 Sep;8(3):768-78.
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