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Chemical Structure : Povorcitinib
CAS No.: 1637677-22-5
Catalog No.: PC-73438Not For Human Use, Lab Use Only.
Povorcitinib (INCB054707) is a potent, selective and oral JAK1 inhibitor with IC50 of 8.9 nM, 52-fold selective over JAK2 (IC50=463 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $238 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Povorcitinib (INCB054707) is a potent, selective and oral JAK1 inhibitor with IC50 of 8.9 nM, 52-fold selective over JAK2 (IC50=463 nM).
Povorcitinib (INCB054707) reduces IFN signaling and ameliorates cutaneous lesions in systemic lupus erythematosus (SLE).
Povorcitinib (INCB054707) dose-dependently reduced the incidence and severity of cutaneous lesion, abrogated lymphoid tissue and spleen enlargement in a preclinical model of cutaneous lupus erythematosus.
| M.Wt | 507.469 | |
| Formula | C23H22F5N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-4-(3-(Cyanomethyl)-3-(3',5'-dimethyl-1H,1'H-[4,4'-bipyrazol]-1-yl)azetidin-1-yl)-2,5-difluoro-N-(1,1,1-trifluoropropan-2-yl)benzamide |
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1. Alavi A, et al. Br J Dermatol. 2022 May;186(5):803-813.
2. Fay B, He X, Margulis A et al. Ann Rheum Dis 2019; 78 (Suppl. 2):221–2.
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