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Chemical Structure : Pralnacasan
Catalog No.: PC-22972Not For Human Use, Lab Use Only.
Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active caspase 1 (interleukin-1β converting enzyme, ICE) inhibitor with Ki of 1.4 nM, inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ.
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Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active caspase 1 (interleukin-1β converting enzyme, ICE) inhibitor with Ki of 1.4 nM, inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ.
| M.Wt | 523.55 | |
| Formula | C26H29N5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rudolphi K, et al. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46
2. Loher F, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):583-90.
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