Pralnacasan | Caspase-1 inhibitor | Probechem Biochemicals

Chemical Structure : Pralnacasan

Pralnacasan (VX-740, HMR 3480)

Catalog No.: PC-22972Not For Human Use, Lab Use Only.

Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active caspase 1 (interleukin-1β converting enzyme, ICE) inhibitor with Ki of 1.4 nM, inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ.

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Biological Activity

Physicochemical Properties

M.Wt	523.55
Formula	C26H29N5O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxamide, N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]octahydro-9-[(1-isoquinolinylcarbonyl)amino]-6,10-dioxo-, (1S,9S)-

References

1. Rudolphi K, et al. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46

2. Loher F, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):583-90.

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Pralnacasan (VX-740, HMR 3480)

Biological Activity

Physicochemical Properties

References

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