Preladenant |CAS:377727-87-2 Probechem Biochemicals

Chemical Structure : Preladenant

CAS No.: 377727-87-2

Preladenant (SCH-420814;SCH 420814;SCH420814)

Catalog No.: PC-42729Not For Human Use, Lab Use Only.

Preladenant (SCH420814) is a potent and highly selective adenosine A2A receptor competitive antagonist with Ki of 1.1 nM.

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25 mg	$168	In stock
50 mg	$258	In stock
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Biological Activity

Preladenant (SCH420814) is a potent and highly selective adenosine A2A receptor competitive antagonist with Ki of 1.1 nM.
Preladenant (SCH420814) has >1000-fold selectivity over all other adenosine receptors.
Preladenant (SCH420814) attenuates hypolocomotion induced by the A2AR agonist CGS-21680.
Preladenant (SCH420814) potentiates L-Dopa -induced contralateral rotations after 6-hydroxydopamine lesions in the medial forebrain bundle in rats (0.1-1 mg/kg); orally active.

Physicochemical Properties

M.Wt	503.5563
Formula	C25H29N9O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO
Chemical Name/SMILES	7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]-1-piperazinyl]ethyl]-

References

1. Neustadt BR, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):967-71.

2. Hodgson RA, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):294-303.

3. Hodgson RA, et al. Exp Neurol. 2010 Oct;225(2):384-90.

Preladenant (SCH-420814;SCH 420814;SCH420814)

Biological Activity

Physicochemical Properties

References

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