Prexasertib |CAS:1234015-52-1 Probechem Biochemicals

Chemical Structure : Prexasertib

CAS No.: 1234015-52-1

Prexasertib (LY-2606368;LY 2606368;LY2606368)

Catalog No.: PC-45427Not For Human Use, Lab Use Only.

Prexasertib (LY-2606368) is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$188	In stock
25 mg	$318	In stock
50 mg	$528	In stock
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Biological Activity

Prexasertib (LY-2606368) is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.
Prexasertib (LY-2606368) potently abrogates the G2-M checkpoint activated by doxorubicin in p53-deficient HeLa cells with EC50 of 9 nM.
Prexasertib (LY-2606368) causes replication catastrophe in vitro and in vivo.
Prexasertib (LY-2606368) shows significant tumor growth inhibition in xenograft tumor models.

Physicochemical Properties

M.Wt	365.3892
Formula	C18H19N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 60 mg/mL
Chemical Name/SMILES	2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-

References

1. King C, et al. Mol Cancer Ther. 2015 Sep;14(9):2004-13.

2. Lowery CD, et al. Clin Cancer Res. 2017 Aug 1;23(15):4354-4363.

3. Sen T, et al. Cancer Res. 2017 Jul 15;77(14):3870-3884.

Prexasertib (LY-2606368;LY 2606368;LY2606368)

Biological Activity

Physicochemical Properties

References

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