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Chemical Structure : Procaspase-3 activator 1541
CAS No.: 1100353-03-4
Catalog No.: PC-62209Not For Human Use, Lab Use Only.
Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM).
Procaspase-3 activator 1541 does not activate procaspases-1 or -7.
Procaspase-3 activator 1541 induces cell death by the fibrillar rather than the soluble form of the compound.
Procaspase-3 activator 1541 induces extensive proteolysis including caspase substrates, yet modulatory profiling reveals that chemi-fibrils form a distinct class from existing inducers of cell death.
| M.Wt | 411.417 | |
| Formula | C24H17N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-8-methoxy-2-oxo-2H-chromene-3-carboxamide |
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1. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76.
2. Zorn JA, et al. J Biol Chem. 2012 Sep 28;287(40):33781-95.
3. Wolan DW, et al. Science. 2009 Nov 6;326(5954):853-8.
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