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Procaspase-3 activator 1541

Chemical Structure : Procaspase-3 activator 1541

CAS No.: 1100353-03-4

Procaspase-3 activator 1541 (Compound 1541)

Catalog No.: PC-62209Not For Human Use, Lab Use Only.

Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM).

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Biological Activity

Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM).
Procaspase-3 activator 1541 does not activate procaspases-1 or -7.
Procaspase-3 activator 1541 induces cell death by the fibrillar rather than the soluble form of the compound.
Procaspase-3 activator 1541 induces extensive proteolysis including caspase substrates, yet modulatory profiling reveals that chemi-fibrils form a distinct class from existing inducers of cell death.

Physicochemical Properties

M.Wt 411.417
Formula C24H17N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-8-methoxy-2-oxo-2H-chromene-3-carboxamide

References

1. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76.

2. Zorn JA, et al. J Biol Chem. 2012 Sep 28;287(40):33781-95.

3. Wolan DW, et al. Science. 2009 Nov 6;326(5954):853-8.

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