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Chemical Structure : Procaspase-3 activator 1541B
Catalog No.: PC-62210Not For Human Use, Lab Use Only.
Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM.
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Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM.
Procaspase-3 activator 1541B shows no activition activity for procaspases-6.
Procaspase-3 activator 1541B shows considerable synergy in activating procaspase-3 in vitro combined with PAC-1, stimulates rapid and dramatic maturation of procaspase-3 in multiple cancer cell lines.
Procaspase-3 activator 1541B effectively reduces tumor burden in a murine lymphoma model combined with PAC-1, but not treated alone.
| M.Wt | 397.39 | |
| Formula | C23H15N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wolan DW, et al. Science. 2009 Nov 6;326(5954):853-8.
2. Botham RC, et al. J Am Chem Soc. 2014 Jan 29;136(4):1312-9.
3. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76.
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