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Chemical Structure : Procaspase-6 inhibitor 12
Catalog No.: PC-73050Not For Human Use, Lab Use Only.
Procaspase-6 inhibitor 12 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.47 uM.
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Procaspase-6 inhibitor 12 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.47 uM.
Procaspase-6 inhibitor 12 binds to pro-C6 at the dimer interface and contacts amino acids Y198, T199 and E214.
Procaspase-6 inhibitor 12 significantly stabilizes procaspase-6.
Procaspase-6 inhibitor 12 prevents the activation of the Caspase-6 zymogen by mHTT1–586 in COS-7 cells.
| M.Wt | 296.305 | |
| Formula | C16H13FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jeremy Murray, et al. ChemMedChem. 2014 Jan;9(1):73-7, 2.
2. Ehrnhoefer DE, et al. Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6.
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