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Procaspase-6 inhibitor 12

Chemical Structure : Procaspase-6 inhibitor 12

CAS No.: 1575392-43-6

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Procaspase-6 inhibitor 12 (Procaspase-6-IN-12)

Catalog No.: PC-73050Not For Human Use, Lab Use Only.

Procaspase-6 inhibitor 12 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.47 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Procaspase-6 inhibitor 12 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.47 uM.
    Procaspase-6 inhibitor 12 binds to pro-C6 at the dimer interface and contacts amino acids Y198, T199 and E214.
    Procaspase-6 inhibitor 12 significantly stabilizes procaspase-6.
    Procaspase-6 inhibitor 12 prevents the activation of the Caspase-6 zymogen by mHTT1–586 in COS-7 cells.

    Physicochemical Properties

    M.Wt 296.305
    Formula C16H13FN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-fluoro-2-(((3-(pyrimidin-2-yl)pyridin-2-yl)amino)methyl)phenol

    References

    1. Jeremy Murray, et al. ChemMedChem. 2014 Jan;9(1):73-7, 2.

    2. Ehrnhoefer DE, et al. Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6.

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