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Procaspase-6 inhibitor 13

Chemical Structure : Procaspase-6 inhibitor 13

CAS No.: 1575392-45-8

Procaspase-6 inhibitor 13 (Procaspase-6-IN-13)

Catalog No.: PC-73051Not For Human Use, Lab Use Only.

Procaspase-6 inhibitor 13 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.38 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Procaspase-6 inhibitor 13 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.38 uM.
    Procaspase-6 inhibitor 13 binds to pro-C6 at the dimer interface and contacts amino acids Y198, T199 and E214.
    Procaspase-6 inhibitor 13 significantly stabilizes procaspase-6.

    Physicochemical Properties

    M.Wt 311.32
    Formula C16H14FN5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(((3-(5-aminopyrimidin-2-yl)pyridin-2-yl)amino)methyl)-5-fluorophenol

    References

    1. Jeremy Murray, et al. ChemMedChem. 2014 Jan;9(1):73-7, 2.

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