Chemical Structure : Progerinin
CAS No.:
2249696-72-6
Progerinin
(SLC-D011)
Catalog No.: PC-24973Not For Human Use, Lab Use Only.
Progerinin (SLC-D011) is a specific, small molecule binding inhibitor of lamin A and progerin, reduces progerin expression and improves aging phenotypes in vitro and in vivo HGPS models.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Progerinin (SLC-D011) is a specific, small molecule binding inhibitor of lamin A and progerin, reduces progerin expression and improves aging phenotypes in vitro and in vivo HGPS models.
Progerinin can extend the life span of LmnaG609G/G609G mouse for about 10 weeks and increase its body weight.
Progerinin can also extend the life span of LmnaG609G/+ mouse for about 14 weeks via oral administration.
Progerinin can induce histological and physiological improvement in LmnaG609G/+ mouse.
Progerinin improves aging-associated alterations in both in vitro and in vivo Hutchinson-Gilford Progeria Syndrome (HGPS) models.
Physicochemical Properties
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M.Wt
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362.43
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Formula
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C23H22O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-7-(cinnamyloxy)-8,8-dimethyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one
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References
1. Kang SM, et al. Cells. 2023 Apr 24;12(9):1232.
2. Kang SM, et al. Commun Biol. 2021 Jan 4;4(1):5.
3. Kang SM, et al. Sci Rep. 2021 Apr 27;11(1):9122.
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