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Purfalcamine

Chemical Structure : Purfalcamine

CAS No.: 1038620-68-6

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Purfalcamine

Catalog No.: PC-62162Not For Human Use, Lab Use Only.

Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM; inhibits proliferation of P falciparum strains (Dd2, FCB, HB3 and W2) with nanomolar EC50s of (171–259 nM); blocks microneme discharge and erythrocyte invasion by P. falciparum merozoites; an anti-malaria parasite agent.

Physicochemical Properties

M.Wt 528.636
Formula C29H33FN8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[4-[[2-[(4-aminocyclohexyl)amino]-9-(3-fluorophenyl)purin-6-yl]amino]phenyl]-piperidin-1-ylmethanone

References

1. Kato N, et al. Nat Chem Biol. 2008 Jun;4(6):347-56.

2. Bansal A, et al. J Biol Chem. 2013 Jan 18;288(3):1590-602.

3. Gaji RY, et al. Antimicrob Agents Chemother. 2014 May;58(5):2598-607.

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