Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-LIM Kinase (LIMK)-Pyr1
Pyr1

Chemical Structure : Pyr1

CAS No.: 83947-94-8

Add to Favorites

Pyr1 (Liminib, Pyr-1)

Catalog No.: PC-70099Not For Human Use, Lab Use Only.

Liminib (Pyr-1) is a novel potent, selective, cell permeable and ATP competitive LIMK inhibitor.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Liminib (Pyr-1) is a novel potent, selective, cell permeable and ATP competitive LIMK inhibitor.
    Liminib (Pyr-1) stabilizes microtubules, induces a cell-cycle arrest at the S-G2-M phases, and blocks actin microfilament dynamics through inhibition of cofilin phosphorylation.
    Liminib (Pyr-1) blocks the invasion and proliferation of breast cancer cells, including paclitaxel-resistant cells, in vitro and tumor growth and metastasis in vivo in tumor xenograft.

    Physicochemical Properties

    M.Wt 382.42
    Formula C24H18N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5,11-dimethyl-1-oxo-2,6-dihydro-1H-pyrido[4,3-b]carbazol-9-yl benzoate

    References

    1. Prunier C, et al. Cancer Res. 2016 Jun 15;76(12):3541-52.

    2. Prudent R, et al. Cancer Res. 2012 Sep 1;72(17):4429-39.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: