Chemical Structure : Pyr6
CAS No.:
245747-08-4
Pyr6
(TRPC3 inhibitor Pyr6)
Catalog No. : PC-43073Not For Human Use, Lab Use Only.
Pyr6 is a potent, selective inhibitor of TRPC3 channel with IC50 of 0.49 uM (thapsigargin-depleted native RBL-2H3 cells for SOCE).
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4307301
Biological Activity
Pyr6 is a potent, selective inhibitor of TRPC3 channel with IC50 of 0.49 uM (thapsigargin-depleted native RBL-2H3 cells for SOCE).Orai1 - and TRPC3-mediated Ca(2+) entry and currents, potently suppresses mast cell activation.
Physicochemical Properties
M.Wt
418.2684
Formula
C17H9F7N4O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-Pyridinecarboxamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-
References
1. Schleifer H, et al. Br J Pharmacol
2. Dragoni S, et al. Biomed Res Int.
3. Chauvet S, et al. Front Pharmacol.
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