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Pyrcoumin

Chemical Structure : Pyrcoumin

CAS No.: 1648814-86-1

Pyrcoumin

Catalog No.: PC-73006Not For Human Use, Lab Use Only.

Pyrcoumin is a competitive inhibitor of dCTP pyrophosphatase 1 (dCTPP1, IC50=3.3 uM), inhibits Wnt signaling with IC50 of 8.4 uM in SuperTOPFlash reporter gene assays.

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    Biological Activity

    Pyrcoumin is a competitive inhibitor of dCTP pyrophosphatase 1 (dCTPP1, IC50=3.3 uM), inhibits Wnt signaling with IC50 of 8.4 uM in SuperTOPFlash reporter gene assays.
    Pyrcoumin dose-dependently decreased the expression of Wnt target genes AXIN2, CCND1 and LEF1 in Wnt-activated HEK293 cells.
    Pyrcoumin inhibited Wnt pathway activity also in HCT116 cells, did not affect the abundance of β-catenin, or other pathway components such as Axin2 and phosphorylated (Ser33/Ser37/Thr41) β-catenin.
    Pyrcoumin impairs the direct interaction of dCTPP1 and USP7.

    Physicochemical Properties

    M.Wt 363.369
    Formula C21H17NO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    methyl 2-(4-methoxyphenyl)-3-methyl-4-oxo-3,4-dihydrochromeno[3,4-b]pyrrole-1-carboxylate

    References

    1. Waldmann H, et al. Angew Chem Int Ed Engl. 2019 Jun 7. doi: 10.1002/anie.201905977.

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