Chemical Structure : Pyrcoumin
Catalog No.: PC-73006Not For Human Use, Lab Use Only.
Pyrcoumin is a competitive inhibitor of dCTP pyrophosphatase 1 (dCTPP1, IC50=3.3 uM), inhibits Wnt signaling with IC50 of 8.4 uM in SuperTOPFlash reporter gene assays.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Pyrcoumin is a competitive inhibitor of dCTP pyrophosphatase 1 (dCTPP1, IC50=3.3 uM), inhibits Wnt signaling with IC50 of 8.4 uM in SuperTOPFlash reporter gene assays.
Pyrcoumin dose-dependently decreased the expression of Wnt target genes AXIN2, CCND1 and LEF1 in Wnt-activated HEK293 cells.
Pyrcoumin inhibited Wnt pathway activity also in HCT116 cells, did not affect the abundance of β-catenin, or other pathway components such as Axin2 and phosphorylated (Ser33/Ser37/Thr41) β-catenin.
Pyrcoumin impairs the direct interaction of dCTPP1 and USP7.
M.Wt | 363.369 | |
Formula | C21H17NO5 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
1. Waldmann H, et al. Angew Chem Int Ed Engl. 2019 Jun 7. doi: 10.1002/anie.201905977.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright