Pyrimethamine |CAS:58-14-0 Probechem Biochemicals

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Chemical Structure : Pyrimethamine

CAS No.: 58-14-0

Pyrimethamine (Pirimecidan;Pirimetamin;RP 4753)

Catalog No.: PC-45409Not For Human Use, Lab Use Only.

Pyrimethamine is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties, interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR, has also been found to reduce the expression of SOD1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	248.7114
Formula	C12H13ClN4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-

References

1. Lange DJ, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14(3):199-204.

2. Wright PD, et al. Neurosci Lett. 2010 Oct 4;482(3):188-92.

3. Martins-Duarte ÉS, et al. Exp Parasitol. 2013 Mar;133(3):294-9.

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Pyrimethamine (Pirimecidan;Pirimetamin;RP 4753)

Biological Activity

Physicochemical Properties

References

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