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Chemical Structure : QC6352
CAS No.: 1851373-36-8
Catalog No.: PC-61739Not For Human Use, Lab Use Only.
QC-6352 is a potent and selective KDM4 family inhibitor with IC50 of 104, 56, 35, and 104 nM for KDM4A, KDM4B, KDM4C, and KDM4D, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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QC-6352 is a potent and selective KDM4 family inhibitor with IC50 of 104, 56, 35, and 104 nM for KDM4A, KDM4B, KDM4C, and KDM4D, respectively.
QC-6352 displays high selectivity over other KDM family members, with the exception of KDM5B (IC50=750 nM).
QC-6352 shows a promising cellular potency (KYSE-150 EC50=3.5 nM, H3K36 MOA=1.5 nM).
QC-6352 has excellent physical properties and drug-like characteristics, exhibits favorable in vivo efficacy in a breast cancer PDX model and reduces the tumor initiating cell populations which are associated with resistance to chemotherapy treatments.
| M.Wt | 387.483 | |
| Formula | C24H25N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-3-(((6-(methyl(phenyl)amino)-1,2,3,4-tetrahydronaphthalen-1-yl)methyl)amino)isonicotinic acid |
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1. Chen YK, et al. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874.
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