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QC6352

Chemical Structure : QC6352

CAS No.: 1851373-36-8

QC6352 (QC-6352, QC 6352)

Catalog No.: PC-61739Not For Human Use, Lab Use Only.

QC-6352 is a potent and selective KDM4 family inhibitor with IC50 of 104, 56, 35, and 104 nM for KDM4A, KDM4B, KDM4C, and KDM4D, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

QC-6352 is a potent and selective KDM4 family inhibitor with IC50 of 104, 56, 35, and 104 nM for KDM4A, KDM4B, KDM4C, and KDM4D, respectively.
QC-6352 displays high selectivity over other KDM family members, with the exception of KDM5B (IC50=750 nM).
QC-6352 shows a promising cellular potency (KYSE-150 EC50=3.5 nM, H3K36 MOA=1.5 nM).
QC-6352 has excellent physical properties and drug-like characteristics, exhibits favorable in vivo efficacy in a breast cancer PDX model and reduces the tumor initiating cell populations which are associated with resistance to chemotherapy treatments.

Physicochemical Properties

M.Wt 387.483
Formula C24H25N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-3-(((6-(methyl(phenyl)amino)-1,2,3,4-tetrahydronaphthalen-1-yl)methyl)amino)isonicotinic acid

References

1. Chen YK, et al. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874.

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