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QCA276

Chemical Structure : QCA276

CAS No.: 2126819-40-5

QCA276 (QCA 276;QCA-276)

Catalog No.: PC-35400Not For Human Use, Lab Use Only.

QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570; effectively inhibits human BRD2, BRD3, and BRD4 BD1 and BD2 proteins with Ki of 2-20 nM.

    Physicochemical Properties

    M.Wt 401.488
    Formula C22H19N5OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-Benzyl-9-methyl-2-((1-methyl-1H-pyrazol-4-yl)ethynyl)-4H,6Hthieno[2,3-e][1,2,4]triazolo[3,4-c][1,4]oxazepine

    References

    1. Qin C, et al. J Med Chem. 2018 Jul 18. doi: 10.1021/acs.jmedchem.8b00506.

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