QCA276 | BET inhibitor | Probechem Biochemicals

Chemical Structure : QCA276

QCA276 (QCA 276, QCA-276)

Catalog No.: PC-35400Not For Human Use, Lab Use Only.

QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570.

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Biological Activity

QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570.
QCA276 effectively inhibits human BRD2, BRD3, and BRD4 BD1 and BD2 proteins with Ki of 2-20 nM.

Physicochemical Properties

M.Wt	401.488
Formula	C22H19N5OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Benzyl-9-methyl-2-((1-methyl-1H-pyrazol-4-yl)ethynyl)-4H,6Hthieno[2,3-e][1,2,4]triazolo[3,4-c][1,4]oxazepine

References

1. Qin C, et al. J Med Chem. 2018 Jul 18. doi: 10.1021/acs.jmedchem.8b00506.

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QCA276 (QCA 276, QCA-276)

Biological Activity

Physicochemical Properties

References

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