Chemical Structure : QP6126
CAS No.:
3027434-53-0
QP6126
(QP-6126)
Catalog No.: PC-28153Not For Human Use, Lab Use Only.
QP6126 is a highly potent, orally bioavailable inhibitor of Glutaminyl-peptide cyclotransferase-like protein (QPCTL) with IC50 of 2.3 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
QP6126 is a highly potent, orally bioavailable inhibitor of Glutaminyl-peptide cyclotransferase-like protein (QPCTL) with IC50 of 2.3 nM.
QP6126 dose-dependently inhibits the formation of pGlu-CD47 in human HEK293T cells and melanoma A375 cells, also significantly and dose-dependently suppresses the binding of recombinant mouse SIRPα protein to CD47 in B16F10 cells.
QP6126 reduces pGlu-CD47, disrupts CD47-SIRPα interaction, and sensitizes melanoma cells to macrophage phagocytosis.
QP6126 exhibited orally active antitumor effects that synergized with anti-PD-1 therapy in B16F10 melanoma mouse model.
Physicochemical Properties
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M.Wt
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365.43
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Formula
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C20H16D3FN6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(6-fluoropyridin-3-yl)-2-(4-(4-(methyl-d3)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)benzonitrile
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References
1. Xie L, et al. Int Immunopharmacol. 2026 Sep 7;189:117345.
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