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Quinacrine dihydrochloride

Chemical Structure : Quinacrine dihydrochloride

CAS No.: 69-05-6

Quinacrine dihydrochloride (Mepacrine dihydrochloride, SN-390)

Catalog No.: PC-43699Not For Human Use, Lab Use Only.

Quinacrine dihydrochloride (Mepacrine dihydrochloride, SN-390) is an antiprotozoal, antirheumatic and intrapleural sclerosing agen, inhibits histamine N-methyltransferase (HNMT),

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Biological Activity

Quinacrine dihydrochloride (Mepacrine dihydrochloride, SN-390) is an antiprotozoal, antirheumatic and intrapleural sclerosing agen, inhibits histamine N-methyltransferase (HNMT),
Quinacrine also strongly induces p53 function, suppresses both basal and inducible activities of NF-kappaB in RCC and other types of cancer cells.
Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth.

Physicochemical Properties

M.Wt 472.8787
Formula C23H32Cl3N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 44 mg/mL

Chemical Name/SMILES

1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, hydrochloride (1:2)

References

1. Horton JR, et al. Structure. 2001 Sep;9(9):837-49.

2. Gurova KV, et al. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17448-53.

3. Khurana A, et al. Oncotarget. 2015 Nov 3;6(34):36354-69.

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