R-10015 (R10015) is a potent, selective inhibitor of human LIMK1 with IC50 of 38 nM.
R-10015 exhibits good selectivity, with off-target inhibition of only LRRK2 and p70S6K (≥90% inhibition at 1 uM) and moderate inhibition of PKA (76%), ROCK2 (70%), and FLT3 (68%).
R-10015 blocks HIV-1 viral DNA synthesis, nuclear migration, and virion release.
R-10015 has broad-spectrum antiviral effect and inhibits multiple viruses, including EBOV, RVFV, VEEV, and HSV-1.
