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Chemical Structure : R-116010
Catalog No.: PC-70290Not For Human Use, Lab Use Only.
R-116010 is a potent CYP26A1 inhibitor with IC50 of 10 nM, potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with IC50 of 8.7 nM.
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R-116010 is a potent CYP26A1 inhibitor with IC50 of 10 nM, potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with IC50 of 8.7 nM.
R-116010 enhances the ATRA-mediated antiproliferative activity in a concentration-dependent manner.
R-116010 significantly inhibits the growth of murine oestrogen-independent TA3-Ha mammary tumour in vivo.
| M.Wt | 377.51 | |
| Formula | C21H23N5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thatcher JE, et al. Mol Pharmacol. 2011 Aug;80(2):228-39.
2. Van Heusden J, et al. Br J Cancer. 2002 Feb 12;86(4):605-11.
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