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R-116010

Chemical Structure : R-116010

CAS No.: 355860-40-1

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R-116010 (R 116010, R116010)

Catalog No.: PC-70290Not For Human Use, Lab Use Only.

R-116010 is a potent CYP26A1 inhibitor with IC50 of 10 nM, potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with IC50 of 8.7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    R-116010 is a potent CYP26A1 inhibitor with IC50 of 10 nM, potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with IC50 of 8.7 nM.
    R-116010 enhances the ATRA-mediated antiproliferative activity in a concentration-dependent manner.
    R-116010 significantly inhibits the growth of murine oestrogen-independent TA3-Ha mammary tumour in vivo.

    Physicochemical Properties

    M.Wt 377.51
    Formula C21H23N5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [S-(R*,R*)]-N-[4-[2-(dimethylamino)-1-(1H-imidazole-1-yl)propyl]-phenyl]-2-benzothiazolamine

    References

    1. Thatcher JE, et al. Mol Pharmacol. 2011 Aug;80(2):228-39.

    2. Van Heusden J, et al. Br J Cancer. 2002 Feb 12;86(4):605-11.

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