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R-360163

Chemical Structure : R-360163

CAS No.: 883791-50-2

R-360163 (R360163)

Catalog No.: PC-61807Not For Human Use, Lab Use Only.

R-360163 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 16 uM in FP assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    R-360163 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 16 uM in FP assay.
    R-360163 displays 16-fold and 25-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively.

    Physicochemical Properties

    M.Wt 392.371
    Formula C20H16N4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (Z)-3-(2-(2-(1-allyl-2-oxoindolin-3-ylidene)hydrazinyl)-2-oxoacetamido)benzoic acid

    References

    1. Zhang M, et al. ACS Med Chem Lett. 2013 Jan 8;4(2):306-11.

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