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Chemical Structure : R-VK4-40
Catalog No.: PC-47101Not For Human Use, Lab Use Only.
R-VK4-40 is a highly selective, potent and orally available dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, >1500-dold selectivity over D2R.
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R-VK4-40 is a highly selective, potent and orally available dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, >1500-dold selectivity over D2R.
R-VK4-40 dose-dependently inhibited oxycodone self-administration and shifted oxycodone dose-response curves downward, attenuated oxycodone reward and augments analgesia in rodents.
R-VK4-40 produced mild antinociceptive effects without altering open-field locomotion or rotarod locomotor performance.
R-VK4-40 produced mild antinociceptive effects without altering open-field locomotion or rotarod locomotor performance.
| M.Wt | 454.999 | |
| Formula | C25H31ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Vivek Kumar, et al. J Med Chem. 2016 Aug 25;59(16):7634-50.
2. Jordan CJ, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):602-614.
3. Jordan CJ, et al. Neuropharmacology. 2019 Nov 1;158:107597.
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