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Chemical Structure : RA839
CAS No.: 1832713-02-6
Catalog No.: PC-60871Not For Human Use, Lab Use Only.
RA839 is a noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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RA839 is a noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling.
RA839 binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM.
RA839 prevents the induction of both iNOS expression and nitric oxide release in response to lipopolysaccharides in macrophages.
RA839 acutely induces Nrf2 target gene expression in liver in mice.
| M.Wt | 452.569 | |
| Formula | C25H28N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(3S)-1-[4-[(2,3,5,6-tetramethylphenyl) sulfonylamino]-1-naphthyl]pyrrolidine-3-carboxylic acid |
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1. Winkel AF, et al. J Biol Chem. 2015 Nov 20;290(47):28446-55.
2. Nasiri HR, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):526-529.
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