Chemical Structure : RAGE406R
CAS No.:
3034560-21-6
RAGE406R
Catalog No.: PC-25586Not For Human Use, Lab Use Only.
RAGE406R is a small molecule antagonist of RAGE-DIAPH1 interaction, prevents the formation of the RAGE-DIAPH1, binds to cytosolic tail of RAGE (ctRAGE) with Kd of 0.3 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RAGE406R is a small molecule antagonist of RAGE-DIAPH1 interaction, prevents the formation of the RAGE-DIAPH1, binds to cytosolic tail of RAGE (ctRAGE) with Kd of 0.3 nM.
RAGE406R inhibits the ctRAGE activation of DIAPH1. RAGE ligand CML-HSA stimulated migration of murine aortic SMCs in a scratch wound assay with IC50 of 2 nM.
RAGE406R induces significant reduction in CCL2 mRNA expression in primary human macrophages.
RAGE406R (5 mg/kg twice per day by oral gavage) reduced oot pad inflammation score in murine models of delayed type hypersensitivity (DTH) and impaired wound healing in mice with type 2 diabetes (T2D).
Physicochemical Properties
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M.Wt
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412.49
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Formula
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C25H24N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-4-(morpholinomethyl)-2-(4-(5-oxopyrrolidin-2-yl)phenyl)quinoline-7-carbonitrile
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References
1. Theophall GG, et al. Cell Chem Biol. 2025 Oct 1:S2451-9456(25)00291-0.
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