Chemical Structure : RAP-103
CAS No.:
RAP-103
(all-D-TTNYT)
Catalog No.: PC-21102Not For Human Use, Lab Use Only.
RAP-103 is an orally active, stabilized pentapeptide analog of DAPTA (D-ala-peptide T-amide), and multi-chemokine receptor antagonist.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RAP-103 is an orally active, stabilized pentapeptide analog of DAPTA (D-ala-peptide T-amide), and multi-chemokine receptor antagonist.
RAP-103 inhibits chemokine ligands from binding to four specific chemokine receptors: CCR2, CCR5, CCR8, and CXCR4.
RAP-103 exhibits potent antagonism for both CCR2 (IC50 = 4.2 pM) and CCR5 (IC50 = 0.18 pM) in monocyte chemotaxis assays and CCR8 (IC50 = 7.7 fM).
RAP-103 attenuates behavioral hallmarks of neuropathic pain, such as mechanical allodynia and thermal hyperalgesia.
RAP-103 also downregulates corresponding molecular hallmarks of neuropathic pain such as phagocytosis, immune cell migration, and cell membrane ruffling.
RAP-103 inhibits opioid-derived respiratory depression, reduces opioid reinforcement and physical dependence, and normalizes opioid-induced dysregulation of mesolimbic chemokine receptors in rats.
Physicochemical Properties
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M.Wt
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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