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Chemical Structure : RAS activator compound 1
Catalog No.: PC-35921Not For Human Use, Lab Use Only.
RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM.
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RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM.
RAS activator compound 1 targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2.
| M.Wt | 449.983 | |
| Formula | C25H28ClN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Howes JE, et al. Mol Cancer Ther. 2018 May;17(5):1051-1060.
2. Burns MC, et al. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6.
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