RAS activator compound 1 |CAS:1579978-17-8 Probechem Biochemicals

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Chemical Structure : RAS activator compound 1

RAS activator compound 1

Catalog No.: PC-35921Not For Human Use, Lab Use Only.

RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM.
RAS activator compound 1 targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2.

Physicochemical Properties

M.Wt	449.983
Formula	C25H28ClN5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-N-(1-((5-chloro-1H-indol-3-yl)methyl)piperidin-4-yl)-3-(1H-indol-3-yl)propanamide

References

1. Howes JE, et al. Mol Cancer Ther. 2018 May;17(5):1051-1060.

2. Burns MC, et al. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6.

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