Chemical Structure : RBI2
CAS No.:
420096-48-6
RBI2
(Ribosome biogenesis inhibitor 2)
Catalog No.: PC-20939Not For Human Use, Lab Use Only.
RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM.
RBI2 inhibits cell growth and proliferation in cell viability assays in A375 cells (IC50=680 nM), with limited effect of on the proliferation of our non-cancer cell control, HUVECs.
RBI2 inhibits anchorage independent and clonogenic growth.
RBI2 inhibits rRNA synthesis differently from other previously described ribosome biogenesis inhibitors, potentially acting through a novel pathway that upregulates the turnover of premature rRNAs.
Physicochemical Properties
|
M.Wt
|
459.52
|
|
Formula
|
C24H21N5O3S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
O=C(N)C(C#N)C(C1=C(O)N(C2=NC(C3=CC=C(OC)C=C3)=CS2)N=C1C)C4=CC=CC=C4
|
References
1. Catherine E Scull, et al. Biochem J. 2019 Aug 9;476(15):2209-2219.
Contact Us
sales@probechem.com
