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Chemical Structure : RBI2
Catalog No.: PC-20939Not For Human Use, Lab Use Only.
RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM.
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RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM.
RBI2 inhibits cell growth and proliferation in cell viability assays in A375 cells (IC50=680 nM), with limited effect of on the proliferation of our non-cancer cell control, HUVECs.
RBI2 inhibits anchorage independent and clonogenic growth.
RBI2 inhibits rRNA synthesis differently from other previously described ribosome biogenesis inhibitors, potentially acting through a novel pathway that upregulates the turnover of premature rRNAs.
| M.Wt | 459.52 | |
| Formula | C24H21N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Catherine E Scull, et al. Biochem J. 2019 Aug 9;476(15):2209-2219.
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