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Chemical Structure : RDN009
CAS No.: 2839429-24-0
Catalog No.: PC-72472Not For Human Use, Lab Use Only.
RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $228 | In stock | |
| 5 mg | $368 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM.
RDN009 showed good selectivity for ZAP-70 over structurally related Syk (IC50>1,000 nM).
RDN009 displayed potent inhibitory effects on T cell proliferation, activation, and inflammatory cytokine production.
RDN009 demonstrated covalent linkage to ZAP-70 protein at C346.
RDN009 is a potent and selective probe of ZAP-70 for further development for treatment of autoimmune diseases.
| M.Wt | 509.951 | |
| Formula | C24H24ClN7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-((3-(2-chloroacetamido)benzyl)amino)-7-((3,5-dimethoxyphenyl)amino)imidazo[1,2-c]pyrimidine-8-carboxamide |
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1. Danni Rao, et al. Eur J Med Chem. 2021 Jul 5;219:113393.
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