Chemical Structure : RETRA hydrochloride
CAS No.:
1173023-52-3
RETRA hydrochloride
Catalog No.: PC-62080Not For Human Use, Lab Use Only.
RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft; increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.
Physicochemical Properties
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M.Wt
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305.8
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Formula
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C11N11NO3S2.HCl
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrochloride
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References
1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.
2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51.
3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85.
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