RETRA hydrochloride |CAS:1173023-52-3 Probechem Biochemicals

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Chemical Structure : RETRA hydrochloride

RETRA hydrochloride

Catalog No.: PC-62080Not For Human Use, Lab Use Only.

RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft; increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.

Physicochemical Properties

M.Wt	305.8
Formula	C11N11NO3S2.HCl
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrochloride

References

1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.

2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51.

3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85.

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