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Chemical Structure : RF036
Catalog No.: PC-72450Not For Human Use, Lab Use Only.
RF036 (MMP-13i) is a potent, highly selective MMP-13 inhibitor with IC50 of 2.7 nM, does not inhibit MMP-1, -2, -8, -9, and -14 (IC50 values >5,000 nM).
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RF036 (MMP-13i) is a potent, highly selective MMP-13 inhibitor with IC50 of 2.7 nM, does not inhibit MMP-1, -2, -8, -9, and -14 (IC50 values >5,000 nM).
RF036 (MMP-13i) potently inhibits type II collagen cleavage with IC50 of 8.1 nM in in vitro type II collagen cleavage assays.
RF036 (MMP-13i) potently suppressed wild-type osteoclast formation in vitro at concentrations <100 nM.
RF036 (MMP-13i) strongly inhibited multiple myeloma viability.
RF036 (MMP-13i) treatment delayed multiple myeloma growth in immunocompetent syngeneic mouse model of multiple myeloma, inhibited multiple myeloma promotes systemic skeletal bone disease.
| M.Wt | 498.573 | |
| Formula | C25H27FN4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen Hao Lo, et al. Cancer Res. 2021 May 1;81(9):2415-2428.
2. Choi JY, et al. J. Med. Chem 2017, 60, 5816–5825.
3. Fuerst R, et al. Bioorg. Med. Chem 2018, 26, 4984–4995.
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