Catalog No.: PC-72450Not For Human Use, Lab Use Only.
RF036 (MMP-13i) is a potent, highly selective MMP-13 inhibitor with IC50 of 2.7 nM, does not inhibit MMP-1, -2, -8, -9, and -14 (IC50 values >5,000 nM).
RF036 (MMP-13i) is a potent, highly selective MMP-13 inhibitor with IC50 of 2.7 nM, does not inhibit MMP-1, -2, -8, -9, and -14 (IC50 values >5,000 nM).
RF036 (MMP-13i) potently inhibits type II collagen cleavage with IC50 of 8.1 nM in in vitro type II collagen cleavage assays.
RF036 (MMP-13i) potently suppressed wild-type osteoclast formation in vitro at concentrations <100 nM.
RF036 (MMP-13i) strongly inhibited multiple myeloma viability.
RF036 (MMP-13i) treatment delayed multiple myeloma growth in immunocompetent syngeneic mouse model of multiple myeloma, inhibited multiple myeloma promotes systemic skeletal bone disease.
